Search results for "Insulin mimetic"

Malonato complexes of oxidovanadium(IV): Synthesis, structural characterization and exploration of their insulin mimetic properties

2011

Abstract Several bis-malonatooxidovanadium(IV) complexes of the general type [M2(H2O)n][VO(mal)2(H2O)] (where M = Li(1), Na(2), K(3), Cs(4) and NH4(5); n = 3.5, 1, 3, 1 and 1, respectively) were isolated in good yield and high purity. These complexes were fully characterized by various physicochemical techniques (elemental analysis, UV–Vis, IR, EPR, CV, etc.) complexes 1, 2 and 3 were structurally characterized by single crystal X-ray diffraction technique. In vivo antidiabetic properties of bis-malonato complexes 1, 2, 3 and 5 have been studied using Streptozotocin induced diabetic rats. Significant lowering of blood sugar level has been noticed. At the same time these complexes were found…